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The Human Genome Project

"To suppose that earth is the only populated world in infinite space is as absurd as to believe that in an entire field sown with millet, only one grain will grow", said Metrodorus of Chios in the 4th century B.C.

 

A DNA molecule consists of a ladder, formed of sugars and phosphates, and four nucleotide bases: adenine (A), thymine (T), cytosine (C), and guanine (G). The genetic code is specified by the order of the nucleotide bases, and each gene possesses a unique sequence of base pairs. Scientists use these base sequences to locate the position of genes on chromosomes and to construct a map of the entire human genome.

 

The Human Genome Project (HGP) is an international research program designed to construct detailed genetic and physical maps of the human genome, to determine the complete nucleotide sequence of human DNA, to localize the estimated 50,000-100,000 genes within the human genome, and to perform similar analyses on the genomes of several other organisms used extensively in research laboratories as model systems. The scientific products of the HGP will comprise a resource of detailed information about the structure, organization and function of human DNA, information that constitutes the basic set of inherited "instructions" for the development and functioning of a human being. Successfully accomplishing these ambitious goals will demand the development of a variety of new technologies. It will also necessitate advanced means of making the information widely available to scientists, physicians, and others in order that the results may be rapidly used for the public good. Improved technology for biomedical research will thus be another important product of the HGP. From the inception of the HGP, it was clearly recognized that acquisition and use of such genetic knowledge would have momentous implications for both individuals and society and would pose a number of policy choices for public and professional deliberation. Analysis of the ethical, legal, and social implications of genetic knowledge, and the development of policy options for public consideration are therefore yet another major component of the human genome research effort.

 

The Human Genome project revealed that human beings have 30,000-40,000 genes. That number is much lower than expected.

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